The year is 1827. In Virginia, young Jacob Wheeler dreams of adventure. Leaving his family behind, he joins renowned mountain man Jedediah Smith on an expedition to California. Meanwhile, a young Lakota holy man, Loved by the Buffalo, receives disturbing visions about the coming of the white man and the demise of the buffalo. When his sister, Thunder Heart Woman, is saved by Jacob, the lives of the two families become forever intertwined.