The son of the famous doctor Gu Feng in Qingyuantang pharmacy was accidentally drowned and Gu Feng’s mother blamed his death on their butler, Fang Cheng. Fang Cheng felt grudged, as his bastard Qiang Wei with his mistress named He Xiu has nowhere to foster her. He secretly substituted his daughter for Gu Feng’s daughter Ren Dong who was once fostered elsewhere. Qiang Wei was brought to Gu family and raised up in a well-off environment, while Ren Dong was raised by He Xiu in a poor family. After they grew up, Ren Dong accidentally got a job in Qingyuantang pharmacy and met with Han Chong, who suffered many hardships in his life. Her optimistic nature and medical talent had soon made her popular in the pharmacy.

Growing up in dysfunctional households, three individuals who are unrelated by blood treat each other like family as they yearn for the love that they cannot find at home. Eldest brother Ling Xiao, second brother He Ziqiu, and youngest sister Li Jianjian grow up together, experiencing life’s joy and strife as they support each other’s chosen paths. As Ling Xiao and He Ziqiu graduate from high school, they return to their original families. Five years later, the three are reunited, but the heartaches from their complicated family past becomes a shadow that constantly lingers. Can they finally fix their personal issues to become better versions of themselves?