In 1916 Shanghai, Mei Li marries into the Tian family to protect her brother, managing their pharmacy. After tragic losses, she opens her own drug store while facing opposition to her desires and a catastrophic police raid.

Legend says that after Nuwa repaired the heavens, she left behind stones with mysterious powers. Ancient evil practitioners used these stones for soul-seizing, seeking immortality. The righteous opposed this, leading to a conflict in which the last two stones vanished. Taoist practitioners Yun Tianlan and his disciple Feng Ming discovered the stones and created a barrier in the Qingyun Realm to protect them from evil sects.