"No Good" Tsunayoshi Sawada is next in line to become boss of the powerful Vongola mafia family. The Vongolas' most powerful hitman, a cursed gun-toting infant named Reborn, is sent to teach Tsuna how to be a boss.

Nina, thinking it was a lolly, swallows an object called "Crystal Pearl". But the candy turns out to be a test for the magicians. To retrieve the crystal, a special medicine has to be made so now Zero and Ichii, the magicians, have to protect her from others while waiting for the medicine to be completed.

Aya Akabane is anything but typical. She's arrogant, believes her bra is a fashion accessory that's meant to be worn in public, and takes out her aggression on her closest friends – especially poor Konatsu, who is frequently picked up and spun around by her ponytail. Together with her friends, Aya enjoys an action-packed, event-filled high school life, whether she's trying to steal the panties her friends are wearing or secretly trying to film her classmates' underwater!

Ginko, a Mushi master, travels from place to place researching the Mushi and helping people who are suffering because of it.