Based on the four-panel comic strip that follows the lives of a group of high school students and teachers, this anime features a compilation of comedic vignettes during a typical day in class over the course of three years.

Miki's parents come home from their vacation to announce that they are getting a divorce. But what is more shocking is that they have switched partners with another couple! And to top things off, this other couple has a handsome son, Yuu, who Miki begins to develop feelings for. To make things more disturbing, everyone moves into one house. What will everyone think about Miki's family lifestyle?

Several hundred years after Anthrasax destroyed modern civilization, a group of four lords plans to set this old god free once again. To prevent this from happening, a former ally of the four is released from his 15 year imprisonment. Dark Schneider, a sorcerer who once tried to conquer the world, now fights to save it.

In His and Her Circumstances, like a drug, Yukino Miyazawa was addicted to admiration and praise from those around her. She worked hard to become the perfect student, the perfect girl. But that was before… him. Souichirou Arima. The instant she met him, she hated him. Without even trying, he snatched the very glory from her hands by easily acing the high school entrance exam that should have made her the class representative. To take back what is rightfully hers, Yukino is putting all her efforts into plotting her revenge – but was love part of the plan?

In His and Her Circumstances, like a drug, Yukino Miyazawa was addicted to admiration and praise from those around her. She worked hard to become the perfect student, the perfect girl. But that was before… him. Souichirou Arima. The instant she met him, she hated him. Without even trying, he snatched the very glory from her hands by easily acing the high school entrance exam that should have made her the class representative. To take back what is rightfully hers, Yukino is putting all her efforts into plotting her revenge – but was love part of the plan?

Kintaro Oe is a 25-year-old boy who left Tokyo University and now lives a simple life, traveling by bicycle to learn everything he can about the world.