The son of oligarch Sylvestre Sergeev, Sasha, fled from the university in London, where he studied finance, and entered the astronomical department of the physics department of a Moscow university. Sylvester Andreevich wants to return his son to his former life, but he wants to live "among the people" and wants to achieve everything in life himself. In parallel with this, many funny situations happen to the heroes of the series.

Sasha and Tanya have graduated and moved out of the dormitory. They now live with their son Alyosha in their own two-room apartment in the Moscow suburb of Yuzhnoe Butovo. And, boy, are their neighbors ever weird.

The "Big Difference" is created not only for the audience, but also for those who became the hero of the parody - TV presenters and actors. A guest who comes to the studio seems to see himself through a magnifying glass, because all the details are taken into account in the parody: the character's manner of dressing, speaking, diction features, plastic, makeup, hairstyle. The uniqueness of the project is that in addition to entertainment, the program also has a developmental function. After all, our guest, who is being parodied, has a chance to look at himself from the outside, to see his shortcomings and advantages. Some people like themselves, and some don't. But the main thing is that no one remains indifferent.

The hostel number 3, in which the heroes lived, is being demolished, and three guys (Michael, Anton and Kuzya) are relocated to a new hostel. In the new building they are settled in block number 510 with the girls Christina, Yana and Masha. Kuzya begins to date Masha, and Anton dates Christina. Later Kuzya leaves for Agapovka, the botanist Valentin is settled instead.

Humanity knows two types of logic: male and female. In the new TNT show, we do not push them together, but rather make them work for one common result. Star couples, partners on the set, just good friends and acquaintances will together try to build logical links between the most seemingly illogical events, objects or facts.