During the Kyoho period in the reign of Tokugawa Yoshimune, there is a gang of thieves active not just in Edo but also the Tokaido and the Nakasendo, and all across the Kansai region, stealing large sums of money with skillful techniques. They only target the very wealthy and never kill or injure people. They appear with the clouds and disappear like the mist. On the night that the beautiful Ochiyo is to become the bride of a dry goods dealer, a large amount of money hidden inside the shop is stolen. The gang disappears without injuring anyone. It was a two-year plan to marry Ochiyo off so that she could bring them in. The leader of this gang is Kumokiri Nizaemon, the greatest bandit of all time. He keeps a rein on his highly-skilled and notorious followers Nanabake no Ochiyo, Kinezumi no Kichigoro, Subashiri no Kumagoro, Ingakozo Rokunosuke and others.

Dormant, experimental cells begin to awaken inside their human hosts, turning them into creatures called 'Amazons'. Two Amazons- Jin Takayama and Haruka Mizusawa- transform into Kamen Riders Amazon Alpha and Amazon Omega, aiming to exterminate the growing threat.

In a corner of Tohoku, Gouchi Shinhito runs a worship shop that solves the troubles of clients with prayers. Among her consultations is an inexplicable mysterious phenomenon that she cannot handle, and since she herself was 14 years old, she has been tormented by the existence of a mysterious girl... The story that her township saw and heard, the story of her township itself will be revealed!