In Italy, a woman becomes involved in a series of unauthorized exorcisms during her mission to discover what happened to her mother, who allegedly murdered three people during her own exorcism.

Cancer-terminal tycoon Peter Murdoch's secret Wexel Hall Pharmaceuticals lab has developed a blood orchid extract cure. To examine why it works optimally in snakes, they also bread a super-anaconda strain. But the original pair escapes, leaving a bloody trail of human corpses. Murdoch runs, instructing his staff to clean up. They keep failing and being eaten like unsuspecting locals, some alive, even after enlisting ruthless big game hunter Hammett. The fast-growing pregnant monster sheds its skin, thus disabling the only tracking device they have.

Harmon is a CIA/DEA enforcer investigating Arab terrorists captured in Mexico. With his team--seductive FBI agent Zara and spy-drone pilot Sharp--he flies to Istanbul and uncovers a brutal plot: Islamic extremists plan to use Sonora drug-smuggling routes to bring deadly weapons, and leaders, into the U.S. To prevent an attack on America, Harmon must turn these two savage forces against one another before his time--and his luck--run out.

In an attempt to rescue their friend from an evil corporation, a group of teenagers end up releasing a horde of bloodthirsty zombies.