A group of young men and women in Dublin in 1916 are embroiled in a fight for independence during the Easter Rising. The story begins with the outbreak of World War I. As expectations of a short and glorious campaign are dashed, social stability is eroded and Irish nationalism comes to the fore. The tumultuous events that follow are seen through the eyes of a group of friends from Dublin, Belfast and London as they play vital and conflicting roles in the narrative of Ireland's independence.

Cat Hogan returns to West Meath upon her mother's sudden death - she has an accident at home and died (or was it an accident?). Blood is about old secrets, older betrayals, mind games and the lies family tell each other.