After accidentally killing his lead star, a has-been hollywood producer turns to an ancient herbal elixir, in the hope that it will save his career. He makes a dark deal that unleashes a band of bloodthirsty, shape-shifting, ferocious beasts on LA.

Phil and his misfit friends score big when they are invited to the party of the century at Bob's house. Known for throwing the craziest drug, sex and booze filled parties, this was sure to be a night to remember. The only problem is that they can't remember a thing. When Phil wakes up realizing that his girlfriend is only hours from knocking on his door, he decides to enlist the help of his friends to try to piece together what was obviously a night worth remembering.