Shortly after the Inter-High of Kagami and Kuroko's second-year, a street basketball team from the USA called Team Jabberwock came to Japan to play a friendly match against a Japanese college-level street basketball team, Team Strky. Despite their best efforts, Strky is brutally crushed by Jabberwock. After the match, the Jabberwock players insult the players from Strky and all of Japanese basketball, claiming Strky's basketball was at the same level as monkeys and telling the players and crowds to quit playing basketball and kill themselves. As a revenge match, Kagetora assembles a dream team of all members of Generation of Miracles plus Kuroko Tetsuya and Kagami Taiga, along with bench players Hyūga Junpei, Takao Kazunari, and Wakamatsu Kōsuke, forming Team Vorpal Swords, with the hopes of reclaiming the pride of Japanese basketball.

A mysterious group called Humarize strongly believes in the Quirk Singularity Doomsday theory which states that when quirks get mixed further in with future generations, that power will bring forth the end of humanity. In order to save everyone, the Pro-Heroes around the world ask UA Academy heroes-in-training to assist them and form a world-class selected hero team. It’s up to the heroes to save the world and the future of heroes in what is the most dangerous crisis to take place yet in My Hero Academia.