In 1934, the second most lucrative business in New York City was running 'the numbers'. When Madam Queen—the powerful woman who runs the scam in Harlem—is arrested, Ellsworth 'Bumpy' Johnson takes over the business and must resist an invasion from a merciless mobster.

From 5 different point of views a story unfolds about three beautiful intoxicated ladies that venture out on a terrorizing crime spree intersecting with dangerous men and others on their own drug induced killing sprees in Detroit.