Rocky, Colt and TumTum must battle an evil wealthy toxic waste dumper in order to save a local Indian tribe and their friend Joe. The 3 Ninjas must help find Joe's father and find a secret disk that contains evidence that could stop the toxic landfill that is destroying the Indian community. However the town is owned by the rich man and he controls the police and even the mayor. They must fight a motorcycle gang and renegade cowboys in this non-stop ninja adventure.

Squanto is a high-born Indian warrior from a tribe on the Atlantic coast of North America which devotes its life to hunting and rivalry with a neighboring tribe. Everything changes forever after a ship arrives from England, prospecting the region's commercial potential for the rich Sir George, who uses all his wealth and influence only for ever greater profit. When it returns, several Indians find themselves captives on board, including Squanto. The arrogant Christians consider themselves utterly superior to the 'heathen savages' and treat them as brutally as they do beasts. Squanto fights a bear in a circus, not understanding how men can be so cruel to that creature either, and manages a spectacular escape, but where must he go? He finds shelter and help in a rural monastery, where it takes his protector some effort to prevent the others considering the unknown as diabolical. In time sir George's men come looking for him most brutally...

Wounded Civil War soldier, John Dunbar tries to commit suicide—and becomes a hero instead. As a reward, he's assigned to his dream post, a remote junction on the Western frontier, and soon makes unlikely friends with the local Sioux tribe.

The legendary Native American chieftain refuses to go with his people peacefully to the reservation and starts a rebellion.

While being pursued by the U.S. Cavalry, Indians and the white family they have kidnapped learn about each other.