Complex, offbeat Detective Charlie Crews returns to the force after serving time in prison for a crime he didn’t commit. Crews’ new lease on life has provided him with a Zen-like outlook, peace of mind and no need for vengeance, an attitude which can be challenging to maintain when someone he cares about is threatened — or when he is investigating the mystery surrounding the murder he was falsely accused of.

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.