She has a loving family and best friends, laughs and cries from time to time... Madoka Kaname, an eighth grader of Mitakihara middle school, is one of those who lives such a life. One day, she had a very magical encounter. She doesn't know if it happened by chance or by fate yet. This is a fateful encounter that can change her destiny. This is a beginning of the new story of the magical witch girls.

This story takes place in a fictional town, in a fictional country, in a fictional world. One morning, a young lady awakens to find that she has lost all her memories prior to that morning. Her life, her relationships, her very name—all gone. All that's left is a cell phone with numbers and names she doesn't recognize and Orion, a young boy that only she appears to be able to see. With Orion's guidance, she struggles to make sense of herself, a boyfriend she doesn't know and the thousand and one little things that make up a daily life. But with no memories left, the only alternative is to forge new ones, even if that means leaving old loves behind.

Toujou Basara is a high school student whose father has suddenly just remarried. His father then departs overseas leaving Basara with two new beautiful step-sisters. Little does he know, his new sisters, Mio and Maria are actually the new Demon Lord and a succubus!? Almost trapped into a life of servitude, Basara forms a reverse contract by accident and ends up becoming Mio's master! Hijinks ensue as Basara finds himself in one ecchi situation after another. However, Mio's life is in danger as she is pursued by demons and heroes!

Tsubomi Hanasaki is a girl in the second grade of middle school who likes flowers and plants. One day she experiences a weird dream. In that dream, a large blooming tree appears. Suddenly it is losing all of its flowers and a fairy appears. A few days later after Tsubomi has transferred to Meidou Gakuen, suddenly the fairy from the dream appears before her and pleads to Tsubomi to become the legendary warrior Precure and protect the Heart Tree. However, Tsubomi declines as she doesn't think that she would be able to do that. However, a mysterious enemy suddenly strikes and steals the heartflower of Erika Kurumi, Tsubomi's new classmate. Now she doesn't have a choice. To retrieve Erika's heartflower she has to transform into Precure and fight. Working up the courage Tsubomi turns into Cure Blossom and a new chapter of Pretty Cure begins!

When Kouichi arrives at his new school, he immediately senses something frightening in the atmosphere of his new class, something that no student wants to talk about and that seems to be related to a mysterious and silent girl.