Following her graduation from middle school, Yuzuhara Konomi enters the same high school as Kouno Takaaki, her childhood friend. As the new school year begins, they meet their childhood friend Kousaka Tamaki, as well as many new acquaintances. Unbeknownst to the group, their encounters with each other will soon lead to many memorable adventures.

For as long as he can remember, Ichigo Kurosaki has been able to see ghosts. But when he meets Rukia, a Soul Reaper who battles evil spirits known as Hollows, he finds his life is changed forever. Now, with a newfound wealth of spiritual energy, Ichigo discovers his true calling: to protect the living and the dead from evil.

Miki works at her mother's ramen restaurant. She appears normal, but she can become violent when provoked causing issues in their otherwise peaceful lives.

In the big city of Yanagihara, the masses of people and buildings make it a bustling place to exist, and yet, people will meet and fall in love here in this city.

Thirteen-year-old Yasaka is a boy staying at his grandfather's house during his summer vacation. One day he entered a store and met Arashi, a beautiful sixteen-year-old girl working there. After trying to protect her from a man who claims to have been hired by her family to take her back by force, Yasaka ran away with her and now she stays at his grandpa's place with him. It didn't take much time for Yasaka to figure out that his new friend is far from an ordinary girl, as she possesses mysterious powers. The plot thickens when he finds a sixty-year-old picture of Arashi and another girl named Kaja, and to the surprise of all Kaja suddenly appears, and just like Arashi, her appearance hasn't changed at all since then.

A mysterious organization is interested in fledging duelist Shobu Kirifuda's ability to bring Duel Master creatures to life. With the support of his friends, Shobu duels with passion, discipline, and heart as he strives to be like his father and become the next Kaijudo master.

Kyotaro Kakei has always had an affinity towards books in hopes to find answers to his life. With a mentor's promise, he continues to search for a book with his absolute hope. However, this changes when he receives a foretelling message saying that "Today, something will happen that will change your fate. --From the Shepherd." Due to this premonition, his normal school life at Shiomoi Academy becomes entangled due to the optimistic Tsugumi Shirasaki and the Shimoi Happy Project.

Kyotaro Kakei has always had an affinity towards books in hopes to find answers to his life. With a mentor's promise, he continues to search for a book with his absolute hope. However, this changes when he receives a foretelling message saying that "Today, something will happen that will change your fate. --From the Shepherd." Due to this premonition, his normal school life at Shiomoi Academy becomes entangled due to the optimistic Tsugumi Shirasaki and the Shimoi Happy Project.

On her first date with the cutest boy in school, Ichigo is zapped by a mysterious ray that scrambles her DNA with that of the endangered Iriomote wildcat. The next day, Ichigo discovers that she has developed the agility (and occasionally the ears and tail) of a cat, as well as the power to transform into a pink-haired superheroine, Mew Ichigo. She and four other girls, each endowed with the genes of a different "Red Data" animal, have been selected for the top-secret Mew Project, which aims to protect the Earth from an alien menace known as Deep Blue.

The story revolves around four teens - the good-looking twins Asaba Yuuta and Yuuki, the effeminate Matsuoka Shun, and the class head Tsukahara Kaname - who have known each other since early childhood. While they are not necessarily good or bad friends, they continue to hang out well into high school. The half-Japanese transfer student Tachibana Chizuru joins the circle of friends in this comedy about the everyday life of adolescence.

Nagisa Aoi is a new transfer student into one of the three prestigious all-girls Catholic high schools on Astraea Hill: a school called St. Miator (the other two are St. Spica and St. Lelim (known in the anime as Le Rim, for some reason). While getting totally lost on her first day, she stumbles into a clearing with a tree, and also into a girl with long silver hair. Nagisa is immediately smitten with the girl, Shizuma Hanazono, otherwise known as the Etoile of the three schools (the most idolized girl). Shizuma, after picking up a figurine dropped by Nagisa, kisses her on the forehead, leading to Nagisa fainting. After waking up in the school's infirmary, Nagisa then meets her new roommate, Tamao Suzumi. Things, however, will be getting a lot more complicated for the new student than just that.

People's lives have changed because of VR and AR, and an competitive sport has born from these technologies called CB (Circlet Bout). CB can be competed between two schools and became an e-sport that decides the wealth of the schools. It also became the real ability of the school, which depends on not just the students' academic skills, but also on the data based on the sport ability, art, skills, etc.

Even though Masaru is about to graduate from a technical college pretty soon he still has no job. One and only pleasure for him is to spend time at a cafe called “Hidamari”. The cafe is owned by his childhood friend’s Nanami and Kurumi’s parents and they are working there too. One day, he learns another one of his childhood friends is coming back to his town. He says “I wanna meet her soon.”. Triggered by his word, Nanami and Kurumi start to approach him in a very different way than they ever did before…

Handa Shinobu and Naitou Momoko have known each other since childhood. Shinobu fell in love with Momoko from the day they first met. Now in high school, Momoko has forgotten about the past, but Shinobu has not. Both follow their own paths but Shinbobu still hopes for Momoko to remember the promise they made long ago.

An animated spin-off from the Densha Otoko (Trainman) TV drama. In the drama, actor Itoh Atsushi plays the otaku Yamada, whose main love in life is the Mina anime, a cutesy busty heroine with floppy rabbit ears and carrots sticking out her rear. Mina itself is a character homage which triggers back to the Daicon Animation done by GAINAX where a similar nameless bunny girl appeared. Densha Otoko futher featured an opening with scenes which were appearing back in the Daicon Animation.

Tomoya Okazaki is a third year high school student resentful of his life. His mother passed away from a car accident when he was younger, causing his father to resort to alcohol and cigarettes. This results in fights between the two until Tomoya's shoulder is injured in a fight. Since then, Tomoya has had distant relationships with his father, causing him to become a delinquent over time. While on a walk to school, he meets a strange girl named Nagisa Furukawa who is a year older, but is repeating due to illness. Due to this, she is often alone as most of her friends have moved on. The two begin hanging out and slowly, as time goes by, Tomoya finds his life shifting in a new direction.

Takeo Goda is a giant guy with a giant heart. Too bad the girls don't want him! (They always go for his good-looking best friend, Makoto Sunakawa.) Used to being on the sidelines, Takeo simply stands tall and accepts his fate. But one day when he saves a girl named Rinko Yamato from a harasser on the train, his (love!) life suddenly takes an incredible turn! Takeo can hardly believe it when he crosses paths with Rinko again, and he finds himself falling in love with her... But with handsome Suna around, does Takeo even stand a chance?