Six very different New Yorkers go about their lives without realizing the impact they're having on one another—yet. A mysterious web of coincidences will gradually draw these strangers closer, changing the course of their lives forever.

Every day is a matter of life and death in a hectic New York City hospital, but for Nurse Jackie that's the easiest part. Between chronic back pain that won't quit, and a personal life on the constant edge of collapse, it's going to take a white lie here, a bent rule there, and a handful of secret strategies to relieve the pain, and stay one step ahead of total disaster.

In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

In the criminal justice system, sexually-based offenses are considered especially heinous. In New York City, the dedicated detectives who investigate these vicious felonies are members of an elite squad known as the Special Victims Unit. These are their stories.