This endearing drama depicts the lives of five gay friends — in conflict with themselves and each other — at the dawn of the AIDS era. Back in 1978 everything seemed possible. For Phillip and Guy, there was the thrill and exhilaration of first love. For their friends Devon, Jerry and Todd, life was still an open book with so many pages yet to be filled. Ten years later, his friends are all gone and Phillip is left alone to make sense of the joys and sorrows of his past life — as he looks hopefully to the future. The lives of two ordinary men who find love together only to lose it. In an era of easy sex and open relationships they have only two rules: Don't fall in love with others and no jealousy. Still rules are made to be broken. Eventually a single act of forgiveness restores their love.

The nerds are now in control of the university, as a result of Lewis Skolnick and the rest's actions in the two previous movies. A new generation of sportsmen arrive, however, determined on winning the school back. The principle, himself an ex-nerd fighter, helps them, and the nerds return to suppression. Harold Skolnick needs help from his uncle Lewis, the hero of the first two movies. Lewis, however, are not too proud of his nerd past, and won't reveal any of it, much less help his nephew. However, his wife makes him change his mind, and with help from his friends from the first two movies, they start the fight to win the school back, using classic nerd tricks.

The Russians seek help in dealing with the Mafia from the veterans of the Police Academy. They head off to Moscow, in order to find evidence against Konstantin Konali, who marketed a computer game that everyone in the world is playing.

Doctor Baines has been conducting genetic experiments on piranhas and has made them virtually unstoppable. Unfortunately, his assistants, Maggie and Paul, accidentally release the hybrids into the Lost River Lake threatening to destroy everyone in their path. Can they prevent the flesh-eating piranhas from escaping into the ocean and spawning?

Yale scholar Matt Carter introduces his wealthy fiancée, Allison, to his family, and initially everything goes smoothly. However, it isn't long before Allison learns that Matt has lied to her about his relatives to mask their failures and dysfunctions. His brother, Tim, flunked out of school and developed a drinking problem, and Matt struggles to keep his own troubling secret from his less than tolerant parents.

Bernie works at a Las Vegas casino, where he uses his innate ability to bring about misfortune in those around him to jinx gamblers into losing. His imposing boss, Shelly Kaplow, is happy with the arrangement. But Bernie finds unexpected happiness when he begins dating attractive waitress Natalie Belisario.