The Manzoni High School in Milan is the worst in Italy. When the percentage of those promoted falls to 12%, it's time for the last resort: to entrust the classes to the worst of the available teachers.

A shot breaks the silence of the night, four men flee from the scene of the crime. Umberto "Yes and No", the infallible killer of the Caputo clan, has just killed the wrong man. Now he will have to account to the boss. Unfortunately, the victim is the nephew of Tonino O 'Infame, the city's most feared boss. But this does not seem to be the biggest problem: Umberto "Yes and No" hides a terrible secret.

Summer 1994. Berlusconi has come into power and 16-year-old Elena, listening to Nirvana and starting to develop a political consciousness, can't wait to bring him down. Unfortunately her parents have other plans and, like every year, they head to the same boring summer camp. This year however they're all in for a surprise...

Andrea (Riccardo Maria Manera) is a young man who lives with the surprises and hardships of life. He lives with his best friend, seeks to complete his studies and has an ex-girlfriend who plays with him like cat and mouse. When he discovers that he has an incurable disease, the world collapses on him. Can an illness change a person's life... for the better? Thanks to Giulia (Jenny De Nucci), Andrea will understand that the time has come to assume what remains of her own existence.