Set fifteen years in the then-future year 1983, the series tells the tale of the crew and passengers of a sub-orbital transport ship named Spindrift. In the pilot episode, the Spindrift is en route from Los Angeles to London, on an ultra-fast sub-orbital flight. Just beyond Earth's boundary with space, the Spindrift encounters a magnetic space storm, and is dragged through a space warp to a mysterious planet where everything is twelve times larger than on Earth, whose inhabitants the Earthlings nickname "the Giants". The Spindrift crash-lands, and the damage renders it inoperable.

Richard Kimble is falsely convicted of his wife's murder and given the death penalty. En route to death row, Kimble's train derails and crashes, allowing him to escape and begin a cross-country search for the real killer, a "one-armed man". At the same time, Dr. Kimble is hounded by the authorities, most notably dogged by Police Lieutenant Philip Gerard.

Follow the adventures of Steve Austin, cybernetically enhanced astronaut turned secret agent, employed by the OSI, under the command of Oscar Goldman and supervised by the scientist who created his cybernetics, Rudy Wells. Steve uses the superior strength and speed provided by his bionic arm and legs, and the enhanced vision provided by his artificial eye, to fight enemy agents, aliens, mad scientists, and a wide variety of other villains.