In the 14th century, Barcelona is experiencing one of its most prosperous moments. The city has grown to La Ribera, a fishing district in which the largest Marian temple ever known is built: Santa María del Mar. But the construction runs parallel to Arnau Estanyol, a serf of the land who, fleeing the abuses of The feudal lords of the countryside take refuge in Barcelona.

Charting the life of Isabella I of Castile, one of the most important women in Spain’s history, Isabel follows her passionate story from childhood to being crowned Queen. From her political struggles within King Henry IV's court to her wedding to Ferdinand of Aragon, the drama encapsulates the passions, emotions and sacrifices of a woman who refused to just be a figurehead and whose outlook was ahead of her time.