A detective solves the puzzle box that releases the diabolical demon, Pinhead. As those around him begin to meet tragic fates, he sets out to conquer the horrifying villain.

When Eastern European criminals Oleg and Emil come to New York City to pick up their share of a heist score, Oleg steals a video camera and starts filming their activities, both legal and illegal. When they learn how the American media circus can make a remorseless killer look like the victim and make them rich, they target media-savvy NYPD Homicide Detective Eddie Flemming and media-naive FDNY Fire Marshal Jordy Warsaw, the cops investigating their murder and torching of their former criminal partner, filming everything to sell to the local tabloid TV show "Top Story."

When the body of a man is found completely destroyed in the swamps in Louisiana, the medical investigator Sam Rivers is assigned to investigate the murder. He travels with the biologist Mary Callahan to the location where the victim lived in a floating house and he meets his family and friends. They find that Chinese snake-heads genetically engineered that belong to a wealthy hunter are attacking and killing the locals. While the group fights to survive, the hunter Jeff arrives with his team to hunt the predators.

A woman, believing that her husband is having an affair, gets a stranger to proposition him so she can record the encounter.