Jess is a bohemian youth with secrets to hide from his shrewd parents. James feels trapped living with his irritable mother. After meeting for a sexual encounter, the two young men set off on a spontaneous road trip across rural Argentina to reunite with Jess' estranged brother. On their journey, they confront strange occurrences and engage in a ménage à trois affair that brings them closer. Their newly found affection grows, all while discovering a fresh vision of freedom and happiness. JESS & JAMES is a sexually charged road-trip movie, a love story, and a coming-of-age tale, set against the mythical landscape of the Argentinian Pampas.

Eight years after the first installment, Ailén, Fernando, and Nina, meet again in the BAFICI competition. From that reunion, they decide to resume their unfinished project: Tandil/Tromso. They bring along two new collaborators: Martín and Nancy.