Louise Françoise Le Blanc de La Vallière’s name is so long and her spell-casting skills are so poor that everyone at the Tristain Academy of Magic just calls her “Louise the Zero.” Louise’s humiliation only increases during an important second-year test, she inexplicably summons Saito Hiraga, a totally normal teenager from Tokyo. Now she’s stuck with him and Saito’s stuck with the lousy life of being a familiar.

Amano Sakogami is a girl who has an unnatural amount of bad luck. One day, she stumbles into the clubroom of the Better Fortune Research Organization, which consists of a boy and seven other girls who secretly use the power of the luck deities to fight against the Magatsugami, monsters who can affect a person's luck & well-being.