Babylon 5 is a five-mile long space station located in neutral space. Built by the Earth Alliance in the 2250s, its goal is to maintain peace among the various alien races by providing a sanctuary where grievances and negotiations can be worked out among duly appointed ambassadors. A council made up of representatives from the five major space-faring civilizations - the Earth Alliance, Minbari Federation, Centauri Republic, Narn Regime, and Vorlon Empire - work with the League of Non-Aligned Worlds to keep interstellar relations under control. Aside from its diplomatic function, Babylon 5 also serves as a military post for Earth and a port of call for travelers, traders, businessmen, criminals, and Rangers.

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

While attending a Hollywood premiere with a famous action star, a crazed fan pulls a gun—but her movie hunk turns into a coward, and it's Vallery who becomes the hero. Suddenly, she's thrown into a world of action and danger as owner of a Hollywood protection agency, Vallery Irons Protection (V.I.P.), taking risks to protect others at a price few are willing to pay.