This is the continuing saga of the Cartwrights, only none of the original Cartwrights are here anymore but their sons. Ben and Hoss have passed on, and Little Joe is MIA; he went with Teddy Roosevelt and is currently missing. Ben's brother, Aaron is now in charge of the Ponderosa, and Little Joe's wife Annie also lives there. His son, Benjamin has come back fom the East. Charlie Poke is a man who owes his life to Ben Cartwright and is now the ranch foreman, and is not exactly on good terms with Aaron. Aaron has allowed a mining company access to mine on the Ponderosa, but the man in charge has other ideas. And Hoss' son Josh whom no one has seen before, has come to the Ponderosa to kill Hoss cause he thinks Hoss deserted him and his mother not knowing that Hoss died before he could go back to bring his mother back to the Ponderosa.

A man with a grudge against the late Little Joe seeks revenge on the Cartwrights and attempts to take over the Ponderosa.

After a rogue band of Pinkerton detectives led by ruthless Charley Siringo bushwhacks reformed outlaw Frank James, he seeks sanctuary on the Ponderosa with the next generation of Cartwrights and his former Civil War compatriots. Will Frank's comrades come to his aid or turn their backs on him? Richard Roundtree also stars in this made-for-TV sequel to the popular Western series.