Obstetrician/gynecologist Mindy Lahiri tries to balance her personal and professional life, surrounded by quirky co-workers in a small medical practice in New York City.

Aspiring singer Tori Vega navigates life while attending a performing arts high school called Hollywood Arts.

Perhaps their strikingly different personalities make the relationship between detective Jane Rizzoli and medical examiner Maura Isles so effective. Jane, the only female cop in Boston's homicide division, is tough, relentless and rarely lets her guard down, while the impeccably dressed Maura displays a sometimes icy temperament — she is, after all, more comfortable among the dead than the living. Together, the best friends have forged a quirky and supportive relationship; they drop the protective shield in each other's company, and combine their expertise to solve Boston's most complex cases.

Sidelined after an accident, hotshot Los Angeles lawyer Mickey Haller restarts his career - and his trademark Lincoln - when he takes on a murder case.