"Golpe de Suerte" tells the lives of three families from different social classes. First there are the Pérez Flores, who live in Neza and are made up of Ignacio, Julia and their children Ronaldo and Wendy. The second family is made up of Miranda Ortiz and her little son Diego; They live in the Roma neighborhood in the house of César Traven, a generous elderly antiques dealer. And finally there are Brenda Uriarte, her brother Tony, her stepmother Constanza and her stepsister Sabrina, an upper middle class family. Each of these families will experience a radical change in their lives the day they win two hundred million pesos.

Paula, a woman who, upon finding out that she suffers from an illness, for which she has 6 to 8 months to live, rethinks her existence and abandons her job as a businesswoman to spend this time with her 3 children. Upon arriving at the town there will be a confrontation between Lorenzo and Pepe's family, a good man with noble feelings who has just asked his wife for a divorce, a selfish woman who is unfaithful to him with Rafa, his own brother. Although the relationship between them begins in a less than cordial manner, Paula and Pepe cannot help but feel attraction for each other. Paula's illness, family secrets from the past, the problems that her children will face, combined with the intrigues of Malena, Pepe's wife, and Rolando, Paula's suitor who, together with Natalia, her partner and supposed best friend, will cause all kinds of conflicts to prevent the union of Paula and Pepe