In San Francisco, Jill Valentine is dealing with a zombie outbreak and a new T-Virus, Leon Kennedy is on the trail of a kidnapped DARPA scientist, and Claire Redfield is investigating a monstrous fish that is killing whales in the bay. Joined by Chris Redfield and Rebecca Chambers, they discover the trail of clues from their separate cases all converge on the same location, Alcatraz Island, where a new evil has taken residence and awaits their arrival.

A pair of mice attempt to board Noah's Ark: Vini, a charismatic poet with terrible stage fright, and Tito, a talented and charming guitarist. When the rains come, only one male and one female of each species is allowed on Noah's Ark. With the help of an ingenious cockroach and fate's good luck, Vini and Tito sneak their way onto the Ark and together avert a showdown among the ships carnivores and plant eaters. All the while, the animals perform a series of classic songs inspired by world renowned poet, Vinicius de Moraes. Can these talented stowaways use music to break the tension and help these cooped up creatures survive the 40 days and 40 nights together?