When three friends finally come to after a raucous night of bachelor-party revelry, they find a baby in the closet and a tiger in the bathroom. But they can't seem to locate their best friend, Doug – who's supposed to be tying the knot. Launching a frantic search for Doug, the trio perseveres through a nasty hangover to try to make it to the church on time.

Lisa: A 25 years old pretty girl. She lives alone and works at the magazine Cosmopolitan. She is disappointed by the relations with men. She has a relation with a guy called Giannis, who is not that interested in her. Until one day, when she meets Paris ...

"Lost Paradise", the code of an experiment that took place in the middle of nowhere, never to be completed. A pair of crazy people, Stelios and Eva, participate in the experiment until Eva is killed ...

Galia accidentally kills her drug dealer and calls her friend to help dispose of the body. While trying to figure out what to do they have constant interruption by addicts looking for a fix.

Entirely made in California, the film brings together 30 American and European actors in an epic which crosses the mythical territories of that cinematic land from Zabriskie Point to Mulholland Drive. California is revisited through the movie memories incarnated by the very presence of famous actors and actresses. "The American Tetralogy" is a way of staging reality which questions the fictional nature of the movies.