Suffering from acute kidney failure, Boonmee has chosen to spend his final days surrounded by his loved ones in the countryside. Surprisingly, the ghost of his deceased wife appears to care for him, and his long lost son returns home in a non-human form. Contemplating the reasons for his illness, Boonmee treks through the jungle with his family to a mysterious hilltop cave—the birthplace of his first life.

Min is an illegal Burmese immigrant living in Thailand who has contracted a mysterious painful rash covering his upper body. His girlfriend, Roong, and a middle-aged woman, Orn, take him to see a doctor. Min pretends that he cannot speak because he is not fluent in Thai and speaking would reveal him to be an illegal immigrant.