The Lucy–Desi Comedy Hour is a collection of thirteen one-hour specials airing occasionally from 1957 to 1960, and originally served as part of Westinghouse Desilu Playhouse. Its original network title was The Ford Lucille Ball-Desi Arnaz Show for the first season, and The Westinghouse Desilu Playhouse Presents The Lucille Ball-Desi Arnaz Show for the following seasons. It was the successor to the classic comedy, I Love Lucy, and featured the same major cast members. The production schedule avoided the grind of a regular weekly series. Desilu produced the show, which was mostly filmed at their Los Angeles studios with occasional on-location shoots at Lake Arrowhead, Las Vegas and Sun Valley, Idaho. CBS reran the show under the "Lucy-Desi" title during the summers of 1962-1967, after which it went into syndication.

Four panelists must determine guests' occupations - and, in the case of famous guests, while blindfolded, their identity - by asking only "yes" or "no" questions.