The Bomans, Bastiaens, Verbeeck, and de Grote families must navigate personal and romantic relationships while dealing with the challenges of their daily lives.

Female detective Hannah Maes leads a police squad, specialized in sexual offenses. A smaller, but important part of the story is about the private quest of Hannah. She investigates a past robbery at her home and the subsequent brutal rape of her mother.

'Familie' is the longest running Belgian soap opera. The Van den Bossches originally had an electronics company, later a holding company that included a clothing chain and a sandwich shop. In the meantime, we closely follow the personal lives of the Van den Bossches and their entourage. Grandma Anna and all her children and grandchildren have been through a lot over time and it doesn't look like their lives will become calmer any time soon.