The story tells what happened at the Oya Institute after the fight in the containers of the High and Low movie. Fujio and Tsukasa were students from Oya High School, but Fujio had to move to a school in the countryside where his grandfather lives to take care of him. While in the institute new students will try to take control.

Suzaku Kanade is the scion of the Suzaku Group who is a bilingual "straight A" student with good looks and great athletic abilities. He is deemed a "celebrity prince" with graceful manners. One day, through his father's introduction, Kanade meets "bad boy prince" Kyogoku Takato who is a charismatic figure among the bad boys in the downtown area. Kanade and Takato who live in completely different worlds and have totally opposite personality start to compete for an "important thing". However, Takato's little brother Kyogoku Ryu, student-union president prince Ayanokoji Aoi, dance prince Red - Tendo Koki, teacher prince Yuki Riichi, and beautician prince Sagasawa Haru also join the competition...

In a town where clubs compete for supremacy, Ando Shintaro, the president of the "Zennichi Civil Engineering" contractors, lived a fulfilling life. Though he wasn't wealthy, he worked hard alongside his fellow colleagues. However, one day, the number one "Club Texas" appear in front of Shintaro and the others and are told that they are now under the umbrella of "Club Texas". Shintaro ponders this and consults with a lawyer regarding buying back the company. However, he is told that it's impossible since "Club Texas" on the number one club. Riki, an employee, goes into "Club Texas" on his own but gets into a fight. Furious, Shintaro rushes in to defeat the person who beat up Riki. However, the number one host there is his older brother that left 10 years ago.

Tokyo Seimenjo is a udon franchise restaurant with the motto "Quick, cheap, and delicious." The restaurant has a lot of regular customers, but their manager has been on maternity leave for the past two months and a reliable staff member has just quit. The four other staff members, Haruto Aoi, Yoshio Midorikawa, Rin Momota, and Setsuko Kimoto, feel uneasy about the situation. At that time, 27-year-old Kotarō Akamatsu is sent to the restaurant as the new manager. He previously worked for a hotel, which is the parent company of Tokyo Seimenjo. Kotarō Akamatsu assures the staff that he knows how things work at a restaurant, but he works there like he is still working at a hotel. He is overly polite to the customers and he seems very nervous while working. The staff members become embarrassed.

Fujio Hanaoka, Seiji Kirihara, Shinya Oochi, Masaya Oochi, Madoka Ishii and Arata Maekawa are friends and they grew up together. They gather together to celebrate Seiji's birthday. The friends dig out a time a capsule they buried 10 years ago. They also write a letter to themselves for 10 years in the future and place it into a new time capsule. Afterwards, the friends experience tragedy.

Thirty-year-old Koume Shingyouji leaves her job at a major building firm to join family-run Marufuku Builders. There she teams up with Gennosuke, the Fukuyama family’s eldest son, and starts working on renovations. Koume and Gennosuke start their renovations by taking the measure not of rooms, but the thoughts and feelings of their clients: What does home mean to them? How do they want to live? What do they value? The team’s empathetic connection is what makes their work, work.

Mihoshi Taiyo is the CEO of investment company Sunshine Fund and self-proclaimed human investor. He holds the belief that "Assets are people. No investor will dispose of their assets." Mihoshi Taiyo approaches people who are having difficulties in their personal lives or business career. He talks to them and proposes doing a start-up together, allowing them to dream again.

Maiko is 24 years old and she has never had a boyfriend. One day, with her father's recommendation, she has a meeting with Harumi about marriage. He is 44-years-old and divorced. At first, Maiko did not want meet Harumi. Yet, as soon as she sees him, she falls in love with him. He is good looking and has a mature personality. Meanwhile, Harumi does not really want to meet Maiko about marriage, but he is unable to say no to her father, who is an important client. He thinks that he will just say no to her during their first meeting, but he becomes attracted to her. On their third date, she gives him paperwork to register for marriage. Harumi and Maiko marry and their marriage life, with a 20 year age gap, begins.

Ichiko and Otoya are happily married, despite not having sex for the last two years. The secret to their happiness is Otoya's affair with Mitsuki, which Ichiko approves. Everything is going well until Otoya rejects Ichiko's advances on the night of their seventh anniversary. In shock, Ichiko seeks advice from her friend who suggests she exercise her right to have a boyfriend of her own.