A scientist, Dr Holander, takes his niece Miranda to Mexico in an attempt to reverse the effects of the alien DNA he used to create her. However the treatment goes horribly wrong, and sets Miranda on a killing spree as she sets out to find a mate.

It all begins when Grandpa Yólotl disappears. Matías, Claudio, Pato, Katy and loyal dog Duke uncover signs that will lead them to a great adventure, facing unimaginable creatures, astonishing characters – that once belonged to an ancient civilization, and a couple of rogue treasure hunters. The promise of their grandfather is the force that will guide these heroes, ready for anything, provided they always stay together and discover the secret of the jade medallion.

What begins as a refuge turns into a battleground when a female professor (Claudia Vega) releases the bitterness she's carried for years into the arms of a much younger lover -- only to find out that he's one of her students. Things become complicated when the student's ex-girlfriend catches wind of the affair and decides to do everything in her power to come between teacher and student. Eleazar Gómez and Gabriela Roel co-star.