Working-class father John Crowley is finally on the fast track to corporate success when his two young children are diagnosed with Pompe disease—a condition that prevents the body from breaking down sugar. With the support of his wife, John ditches his career and teams with unconventional specialist, Dr. Robert Stonehill to found a bio-tech company and develop a cure in time to save the lives of his children. As Dr. Stonehill works tirelessly to prove the theories that made him the black sheep of the medical community, a powerful bond is forged between the two unlikely allies.

Jack Osborne's life changes forever the night men in masks break into his house, threaten his family, and ransack their home. Jack, his mother, and his sister are then forced to enter Witness Security Program. Jack becomes "Zach" and moves to Elko, Nevada, a town in the middle of nowhere. There he meets Sam, the strangest school custodian he has ever encountered, and Catalin, a girl who might make Zach's uprooting worth the trouble. But just as Zach finally begins to piece together a new life, he finds himself in danger again-and this time his actions could determine the fates of everyone he cares about.

Nickelodeon stars feature in vignettes and musical numbers about holiday custom's, all within a larger wrap-around story,

28-year-old Kansas University doctoral student Omar Razaghi wins a grant to write a biography of Latin American writer Jules Gund. Omar must get through to three people who were close to Gund – his brother, widow, and younger mistress – so he can get authorization to write the biography.

A twelve year-old child prodigy teams up with a quirky retiree to solve a crime and save his family from splitting up.

Twins Phoebe and Max are enjoying their superhero lifestyle, but when one 'save' goes awry, the Thundermans are sent back to Hiddenville. While Hank and Barb enjoy their return, and Billy and Nora look forward to a normal high school life, Max and Phoebe are determined to regain their superhero status.

Phone-addicted influencer with anxiety, Callie, meets Leo, a carefree rebel, disconnected from the modern world. In a dysfunctional attempt to change each other, they end up changing themselves.