The series from Neil LaBute aims to examine "the human condition and relationships through a series of conversations between 11 people", whose lives are intertwined, unbeknownst to them. Each episode takes place in a restaurant and is a conversation between two characters. One of the character's storylines then will carry over into the next episode through a conversation with a new character. That character will then be featured in the following episode. The process will continue until the final episode.

Perhaps their strikingly different personalities make the relationship between detective Jane Rizzoli and medical examiner Maura Isles so effective. Jane, the only female cop in Boston's homicide division, is tough, relentless and rarely lets her guard down, while the impeccably dressed Maura displays a sometimes icy temperament — she is, after all, more comfortable among the dead than the living. Together, the best friends have forged a quirky and supportive relationship; they drop the protective shield in each other's company, and combine their expertise to solve Boston's most complex cases.

Set in 1960-1970 New York, this sexy, stylized and provocative drama follows the lives of the ruthlessly competitive men and women of Madison Avenue advertising.