London high-society mouse, Roddy is flushed down the toilet by Sid, a common sewer rat. Hang on for a madcap adventure deep in the sewer bowels of Ratropolis, where Roddy meets the resourceful Rita, the rodent-hating Toad and his faithful thugs, Spike and Whitey.

Set in the futuristic Metro City, Astro Boy (Atom) is a young robot with incredible powers created by a brilliant scientist in the image of the son he had lost. Unable to fulfill his creator's expectations, Astro embarks on a journey in search of acceptance, experiencing betrayal and a netherworld of robot gladiators, before returning to save Metro City and reconcile with the father who rejected him.