This French-German-Dutch biopic on the life of 17th century Dutch master Rembrandt van Rijn is told in flashbacks from the point-of-view of the aged artist. Soon after establishing his career as a painter in Amsterdam, he marries the radiant Saskia. As he makes a name for himself, he can soon afford to buy a large house by teaching wealthy aristocrats how to paint. However, the couple's happiness is short-lived; Saskia dies soon after bearing their son, Titus. Crushed, van Rijn seeks comfort first in the arms of his maid Geertje and then with his second wife, Hendrickje, who gives birth to a daughter. In spite of his genius, van Rijn's determinedly eccentric behavior alienates the very members of the elite who were paying his bills. At one point, the artist's home and belongings, including many of his paintings, are seized and sold for humiliatingly low prices in a rigged auction.

Georges has Down syndrome, living at a mental-institution, Harry is a busy businessman, giving lectures for young aspiring salesmen. He is successful in his business life, but his social life is a disaster since his wife left him and took their two children with her. This weekend his children came by train to meet him, but Harry, working as always, forgot to pick them up. Neither his wife or his children want to see him again and he is driving around on the country roads, anguished and angry. He almost runs over Georges, on the run from the institution since everybody else went home with their parents except him, whose mother is dead. Harry tries to get rid of Georges but he won't leave his new friend. Eventually a special friendship forms between the two of them, a friendship which makes Harry a different person.