Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

After years away from the CIA, Elizabeth McCord is pulled back into the political arena. The newly appointed Secretary of State is tough, fair, and smart, driving international diplomacy, wrangling office politics, and circumventing protocol as she negotiates global and domestic issues, both at the White House and at home.

Special Agent Simone Clark, the oldest rookie in the FBI, is a force of nature, the living embodiment of a dream deferred – and she works together with her new colleagues at the Los Angeles office of the Bureau to bring down the country’s toughest criminals.

From murder and espionage to terrorism and stolen submarines, a team of special agents investigates any crime that has a shred of evidence connected to Navy and Marine Corps personnel, regardless of rank or position.

The New York office of the FBI brings to bear all their talents, intellect and technical expertise on major cases in order to keep their city and the country safe.