A down-and-out Brooklyn detective is hired to track down a singer on an odyssey that will take him through the desperate streets of Harlem, the smoke-filled jazz clubs of New Orleans, and the swamps of Louisiana and its seedy underworld of voodoo.

Brother Rabbit, Brother Bear, and Preacher Fox rise to the top of the crime ranks in Harlem by going up against a con-man, a racist cop, and the Mafia.

After the death of his mother, the evil mutant wizard Blackwolf discovers some long-lost military technologies. Full of ego and ambition, Blackwolf claims his mother's throne, assembles an army and sets out to brainwash and conquer Earth. Meanwhile, Blackwolf's gentle twin brother, the bearded and sage Avatar, calls upon his own magical abilities to foil Blackwolf's plans for world domination -- even if it means destroying his own flesh and blood.

An "underground" cartoonist contends with life in the inner city, where various unsavory characters serve as inspiration for his artwork.