Jejoongwon is the first modern hospital in Korea established in the Joseon era in 1885. Baek Do Yang is a nobleman who gives up his status to enter its ranks. Hwang Jung is a butcher's son who becomes a physician, while Seok Ran enters Jejoongwon as an interpreter but takes on medical training to become a doctor.

This drama portrays the turbulent life of Lee Mi Reuk, a Korean expatriate who fought for the freedom of his country while studying medicine in Tokyo, during the period when Korea was under Japanese colonial rule. He fled to China and eventually settled in Germany.