The future of dueling is revving up! And with it begins a new legend! Yu-Gi-Oh! 5D's! Welcome to New Domino City! Once the playground to legendary duelist Yugi Muto, this sprawling metropolis has since been transformed into a futuristic society where dueling has kicked into overdrive. With recent technological advancements made by KaibaCorp, dueling has undergone a metamorphosis that has revolutionized the makeup and pace of the game! It’s now a heart-pounding, adrenaline-filled and fuel injected competition where duelists ride supercharged hyper cycles called Duel Runners and battle it out in hi-octane contests called “Turbo Duels.” The winners and losers aren’t just separated by skill and strength… but by SPEED! However, for five special duelists, it's not just about winning or losing anymore - it's about survival, for they are the chosen "Signers" who have been marked by destiny to uncover the secrets of the five dragons!

Gon Freecss discovers that the father he had always been told was dead was actually alive the whole time. Ging is a famous Hunter: an individual who has proven themself an elite member of humanity. Gon becomes determined to follow in his father's footsteps, pass the rigorous Hunter Examination.

Toshi-chan and BB live in a hut with a blue sheet on the banks of the Tama River. Having lived there for several years, they are familiar with the area. The two of them gather cans across town from 4 am in the morning and sleep at 7 pm in order to save money on electricity at night. While they do not have substantial income, they are not particularly concerned about money. They are carefree each day and take pride in being homeless men who can support themselves. Nao, a young female actress from a small theatre company, visits Toshi-chan and BB one day. She is playing a heroine who has a grand romance with the leader of homeless men in her next performance and asks to interview them. This is the beginning of a long night for the trio…

Yomiko Readman is a lovable, near-sighted bibliomaniac working as a substitute teacher at a Japanese high school. Her real identity, however, is that of a secret agent for the British Library Special Operations Division. Her codename: "The Paper." The moniker denotes her supernatural ability to freely manipulate paper into any object she can imagine, including tools and weapons in her fight against the powerful and self-serving IJIN (Great Historical Figure) Army! Along with her partner, the enigmatic "Ms. Deep," Yomiko travels across the world in attempt to solve the mystery behind the reincarnation of historical figures and their attempt to control the world.

Inoue Momoko admires her late father, who was a pilot. She begins work as a co-pilot at a low-cost airline. Under Captain Shinkai Kohei’s instructions, who knew her father, Inoue Momoko works hard to become a captain and her boyfriend Umino Daisuke supports her dream too. One day, Inoue Momoko has a problem with a passenger complaining about the limit for carry-on baggage. At that time, Katsuki Tetsuya looks at the situation.

In a world where giant robots are built and used for labor, a special police force of robots is created to handle crimes relating to these machines.