A day in the life of Ethan Collins, a severely depressed, foul-mouthed elementary school teacher whose wife's recent infidelity and departure have left him questioning everything in his life.

A perpetually miserable man finds happiness when he starts dating a manic pixie dream girl, to the befuddlement of his cynical best friend.

Former child star, Guinevere James, is 29, overweight and washed up. She spends night after lonely night on social media sites like Facebook, in a vain attempt to make her life bigger than it seems. She also spends time “FaceStalking” her former co-star, Cadence Stone, who has blossomed into a modelesque A-lister at the top of the game. When Guinevere receives an invitation to a 20th-anniversary special for her signature Gelee commercials, she heads to the event ready for her big comeback only to have her hopes dashed when no one shows up.

Jake Red Cloud, a Native American gun for hire with a mysterious past, needs a place to lay low. With a flashy bankroll, he persuades attractive Jeanine Parker to rent him a room. Jake quickly learns that Parker is nothing but a chain smoking, promiscuous drunk that neglects and ignores her daughter Ann. Desperate for attention, Ann befriends Red Cloud and soon the two develop a spiritual bond of friendship, which leads Jake to the revelation that something in his life is missing. Before he can act his past threatens to extinguish his life and the lives of those around him.

The story frames on 7-year-old Maisie, caught in a custody battle between her mother – a rock and roll icon – and her father. What Maisie Knew is an evocative portrayal of the chaos of adult life seen entirely from a child’s point of view.