A former circus artist escapes from a mental hospital to rejoin his mother - the leader of a strange religious cult - and is forced to enact brutal murders in her name.

“Having broken away from my illusory self, I was desperately seeking a path and a meaning to life.” This phrase perfectly sums up Alejandro Jodorowsky’s biographical project: reconstituting the incredible adventure of his life. Alejandro Jodorowsky was born in 1929 in Tocopilla, a coastal town on edge of the Chilean desert, where this film was shot. It was there where he discovered the fundamentals of reality, as he underwent an unhappy and alienated childhood as part of an uprooted family.

When an opera singer loses her voice, her husband embarks on an odyssey through different underworlds to recover it through supernatural means.

Three episodes: 1) "A Christmas dinner" where the family members fantasize about being somewhere else. The fetishist father wants to put on feminine clothes. The son longs for another transvestite adventure. The daughter yearns to be a singer and destroy the saints of the church with her voice. The youngest son wants to stab everyone dead. 2) "Game of mirrors". Two young classmates kiss on a picnic, but the girl's brother accuses the couple of being immoral. Bizarre things develop. 3) "Tetrahedron". A very fat man faces his girlfriend's longing for love.

Ninón, singer, decides to escape from her frustrated love life, and leaves in search of an old love, finding on the way Alberto, who is on the run from the police

On stormy night in an ugly urban landscape, Ciro Norte, a scientist with wild hair and thick glasses, straps himself to a chair he's has fashioned with wires: lightening strikes, convulsing him. It seems his experiment has not worked. The next day, he drives his jalopy to a bar, sits alone, and weeps. But suddenly, a vortex sucks him into a dream state where he wanders, escapes man-eating fish, confronts his doppelganger, walks through a field of giant flowers, and comes upon Venus herself, buried up to her shoulders in sand. She is a giant, and she takes him to her breast. He wakes from the vortex, back in the bar, his mood transformed.

After his dream project DUNE fell apart, visionary filmmaker Alejandro Jodorowsky took a break from cinema, only to return over a decade later with his most triumphant work: SANTA SANGRE.