In the heavenly vision, the three giants fled from the heaven to haunt the world. The Jade Emperor sent Nezha to the lower realms to look for the three world protectors.

In the sinful city of Heyang, very well-liked Pan Yue married Yang Caiwei, who was despised by everyone. However, Yang Caiwei was murdered on their wedding day. The suspected culprit was none other than Pan Yue. Reborn from death, Yang Caiwei was under the guise of the "wicked woman" Shangguan Zhi. She returned with a fierce demeanor, intending to expose Pan Yue's true colors. As they bravely confronted the Four Major Clans and uncovered the old cases, their hearts drew closer once more. Yang Caiwei discovered that the true culprit was not Pan Yue, who had loved her deeply all along. Just as things seemed to be falling into place, the mastermind behind the scenes set another trap, pushing them into the abyss of despair.

During the great unrest of 4th-century China, war breaks out between the feudal Northern Wei and Southern Liang dynasties. General Lin Xie of Liang takes his only 17-year-old son, Lin Shu, into battle and successfully fights off the hostile Wei army. But when a political rival frames General Lin Xie, it causes the deaths of 70,000 Chiyan army soldiers. Lin Shu is able to escape with his life with the help of a loyal subordinate. Twelve years later, Lin Shu establishes the Jiangzuo Alliance and returns to the capital as the Chief Mei Changsu. When the Northern Wei forces mount another attack, to what lengths will Mei Changsu go to protect his own people?

The plot retells the events in the Chu–Han Contention, an interregnum between the fall of the Qin dynasty and the founding of the Han dynasty.

This Chinese period drama series follows the fortunes of a prominent merchant family engaged in Traditional Chinese Medicine during the waning years of the Ching dynasty. The affairs of this family of doctors/pharmacists (which in those days were one and the same) are intimately linked with social upheavals of the time such as the encroachment of Christian missionaries and foreign imperialism as well as conflicts that inevitably emerge in a large upper class family. Comparable in scope and production value to such recent titles as "Downton Abbey", the lives and character of both masters and servants intertwine in plot lines that spans more than a generation.