65 million years ago, the knights of the Ryusoul Tribe were selected to participate in a war campaign against the dictating Druidon Tribe who sought to rule Earth. But the Druidon's war campaign was halted by the meteor that brought the age of the dinosaurs to an end, forcing them to flee into space. Meanwhile, the Kishiryu were placed in a deep sleep as a failsafe should the Druidon return. The chosen knights choose to live in peace while passing their mantle down across generations. In the present day, the Druidon return to reclaim Earth as the current generation of knights, the Ryusoulgers, battle them with the support of Ui Tatsui and her father Naohisa Tatsui.

Up till 20 years ago, together with his father and 3 other people, Homura Masayoshi was part of the legendary group of thieves that called themselves 「TAKE FIVE」. This group stole from the rich who had acquired their wealth through immoral means. Due to an incident, Masayoshi decided to retire from the group, and settled into his life as a professor of Psychology at a reputable university. One day, he runs into a mysterious homeless woman, who passes him a picture of a Leonardo Da Vinci's painting, which prompts him to re-enter the world of thievery and resurrect 「TAKE FIVE」. Sasahara Rui joined the Burglary Division in the footsteps of her father, who had died in an accident involving a burglary heist. She wows to take down 「TAKE FIVE」 and stop them from stealing again. What was the real reason for the disbanding of 「TAKE FIVE」 20 years ago? Who is the mysterious homeless woman and what is the significance of the Da Vinci picture she had given to Masayoshi? How did Rui's father really died?

Detective Ukyo Sugishita confronts crime on the basis of his own convictions. He has a partner that works for him in the Special Task Unit. For the first 7 seasons, Ukyo’s first partner is Kaoru Kameyama. He is a good-natured, hot-tempered, straightforward and somewhat scattered detective. Beginning in Season 8, Takeru Kanbe replaces Kameyama. Contrary to his predecessor, Takeru is a lanky, cool, conceited and confident detective. From Season 11 to Season 13, Ukyo’s partner is a young detective Toru Kai. Toru is a son of Deputy Director-General of The National Police Agency. But he became a detective by his own effort. And starting with Season 14, Ukyo’s current partner is Wataru Kaburagi, an elite bureaucrat who came to the Metropolitan Police Department on temporary assignment. As the first partner without any career of a police officer, he will face challenging cases together with Ukyo.

Three high school girls are chosen among 700,000 applicants to be on the reality show “Marry the Prince”. They must find their true love in the four princes they encounter.