"Mystery in the Box" is an all-star immersive drama suspense variety show. Huang Lei serves as a variety show producer for the first time, creating a variety show version of Truman's world. He will customize their own "Spiritual Healing Journey" for each of the 10 groups of friends in the circle. One box space, 100 characters, 10 mystery tourists, all stories are closely related to his/her life experiences. Visitors need to interact with the characters in the box, promote the plot, and uncover the truth of the story step by step in various bizarre, hilarious and reversal in order to get out of the box.

Born into a scholarly family, Huang Yimei grows up surrounded by care and affection, displaying artistic talent from a young age. Early in her career, she quickly gains recognition and meets her partner, Zhuang Guodong. They fall in love but eventually drift apart. This period of professional growth gives her a clearer vision for her future, leading her to return to school for further education. After graduation, she marries her senior, Fang Xiewen. However, their divergent career paths lead to a divorce. Huang Yimei then starts her own business and makes a name for herself in the planning for art exhibitions. During this time, she meets her soulmate, Fu Jiaming, but their love story ends tragically with his passing just a few months later. Despite this, Huang Yimei remains resilient, continuing to strive for a more fulfilling life.

The show documents the simplistic lifestyle of living away from the bustling city centers. Each season takes place in a different rural part of China. The cast members are only provided with the basic life necessities and have to take care of everything else such as cooking their own meals and building their own furniture. To "buy" different cooking ingredients and other tools, they have to complete certain tasks assigned by the production crew, such as planting and harvesting crops. Different guests join the cast in each episode and help out with the daily chores. The goal of the program is to bring the audience along on a slower pace of life and to illustrate the joys of a simple lifestyle.