The show stars Pecola, a curious and hyperactive penguin who tries to help the people of Cube Town but often wreaks havoc instead. Pecola is an orphaned penguin who lives with Pecolias, his grandfather. Cube Town is a small, isolated coastal village that contains an art museum, a beach, a lighthouse, and a canal. It is located adjacent to Crescent Bay surrounded by the Rookery Mountains coastal range and serviced by regular ships which deliver mail, food, and other supplies, as well as occasional tourists from a nearby metropolis named Cubic City. The heights above it lead into Glacier Valley which is snowbound even during summer.

After catastrophic earthquakes devastate Japan, one family's resolve is tested on a journey of survival through the sinking archipelago.

Kenzou Tenma, a Japanese brain surgeon in Germany, finds his life in utter turmoil after getting involved with a psychopath that was once a former patient.

Kenzou Tenma, a Japanese brain surgeon in Germany, finds his life in utter turmoil after getting involved with a psychopath that was once a former patient.

When a shapeshifting demon with a thirst for human flesh, known as "youma," arrives in Raki's village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a "Claymore," a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters. After Raki's family is killed, the Claymore saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds the Claymore, known as Clare, and decides to follow her on her journeys. As the pair travel from town to town, defeating youma along the way, more about Clare's organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore.