The future of dueling is revving up! And with it begins a new legend! Yu-Gi-Oh! 5D's! Welcome to New Domino City! Once the playground to legendary duelist Yugi Muto, this sprawling metropolis has since been transformed into a futuristic society where dueling has kicked into overdrive. With recent technological advancements made by KaibaCorp, dueling has undergone a metamorphosis that has revolutionized the makeup and pace of the game! It’s now a heart-pounding, adrenaline-filled and fuel injected competition where duelists ride supercharged hyper cycles called Duel Runners and battle it out in hi-octane contests called “Turbo Duels.” The winners and losers aren’t just separated by skill and strength… but by SPEED! However, for five special duelists, it's not just about winning or losing anymore - it's about survival, for they are the chosen "Signers" who have been marked by destiny to uncover the secrets of the five dragons!

Saku Oyagi returns to his old hometown in order to start school at Soei High School. On the first day, he runs into an old childhood friend: a second year named Mihoshi Akeno. As children, the two used to play together, with Mihoshi, or Mii-chan, being extremely fond of astronomy. After convincing Saku to join the school's astronomy club, another girl, Hime Makita, joins the club in hopes of winning over Saku. This is the story of the 6 club members of the Soei High School Astronomy Club as they soar through their lives, each maturing and changing their outlooks on life.